Darren R. Veach

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

Bhushan Nagar, William G. Bornmann, Patricia Pellicena et al. · PubMed · 2002 · 941 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +13

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

Bhushan Nagar, Oliver Hantschel, Matthew A. Young et al. · Cell · 2003 · 877 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

Sizhi Paul Gao, Kevin G. Mark, Kenneth Leslie et al. · Journal of Clinical Investigation · 2007 · 664 citations · Full text

Medicine, Cancer Biology, Oncology +17

L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition

Cristina R. Antonescu, Klaus J. Busam, Todd D. Francone et al. · International Journal of Cancer · 2007 · 242 citations · Full text

Medicine, Dermatology, Oncology +17

Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases

Patrick M. Reeves, Bettina Bommarius, Sarah L. Lebeis et al. · Nature Medicine · 2005 · 225 citations

Life Sciences, Infectious Diseases, Molecular Biology +14