Concepedia

Conversion From Calcineurin Inhibitor to Mycophenolate Mofetil-Based Immunosuppression Changes the Frequency and Phenotype of CD4+FOXP3+ Regulatory T Cells

Ahmet Demirkıran, Varsha D. K. D. Sewgobind, Joyce van der Weijde, Alice Kok, Carla C. Baan, Jaap Kwekkeboom, Hugo W. Tilanus, Herold J. Metselaar, Luc J. W. van der Laan

Transplantation · 2009 · 84 citations · 21 references

DOI

Abstract

Conversion to MMF increases the percentage and CD25 expression of CD4+FOXP3+ cells indicating that MMF therapy can overturn the repressive effect of CNI on circulating Treg levels and therefore may promote Treg-mediated suppression of alloreactivity.

References

21

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology · 2010 · 5.8K citations · Full text

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.4K citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

Yongqing Wu, Madhuri Borde, Vigo Heissmeyer et al. · Cell · 2006 · 1.2K citations · Full text

, , +7

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

Gláucia C. Furtado, Maria A. Curotto de Lafaille, Nino Kutchukhidze et al. · The Journal of Experimental Medicine · 2002 · 616 citations · Full text

Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance

Silvia Gregori, Mara Casorati, Susana Amuchastegui et al. · The Journal of Immunology · 2001 · 613 citations · Full text