Maternal polymorphisms for methyltetrahydrofolate reductase and methionine synthetase reductase and risk of children with Down syndrome

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome

S J James, Marta Pogribna, Igor P. Pogribny et al. · American Journal of Clinical Nutrition · 1999 · 452 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

The relative effects of paternal and maternal age in mongolism

L. S. PENROSE · Journal of Genetics · 1933 · 405 citations

Social Sciences, Demography, Genetics +12

Susceptible chiasmate configurations of chromosome 21 predispose to non–disjunction in both maternal meiosis I and meiosis II

Neil E. Lamb, Sallie B. Freeman, Amanda Savage-Austin et al. · Nature Genetics · 1996 · 403 citations

Life Sciences, Genetics, Molecular Genetics +14

Polymorphisms in Genes Involved in Folate Metabolism as Maternal Risk Factors for Down Syndrome

Charlotte A. Hobbs, Stephanie L. Sherman, Ping Yi et al. · The American Journal of Human Genetics · 2000 · 371 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Lack of Checkpoint Control at the Metaphase/Anaphase Transition: A Mechanism of Meiotic Nondisjunction in Mammalian Females

Renée LeMaire-Adkins, Kristi Radke, Patricia A. Hunt · The Journal of Cell Biology · 1997 · 286 citations · Full text

Life Sciences, Cell Biology, Genetics +17