Concepedia

Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage

Meidi Gu, Ting Zhang, Wenlong Lin, Zhiyong Liu, Rongrong Lai, Dajing Xia, He Huang, Xiaojian Wang

Cellular Signalling · 2014 · 38 citations · 22 references

DOI

Concepts

References

22

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

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Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

Sandra S. Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi et al. · Science · 2004 · 3.4K citations

, , +17

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Katherine A. Fitzgerald, Sarah M. McWhirter, Daniel C. Rowe et al. · Nature Immunology · 2003 · 2.7K citations

, , +6

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

Sonia Sharma, Benjamin R. tenOever, Nathalie Grandvaux et al. · Science · 2003 · 1.7K citations

, , +17

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

Rongtuan Lin, Christophe Heylbroeck, Paula M. Pitha et al. · Molecular and Cellular Biology · 1998 · 919 citations

, , +16