Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria

Prediction of protein antigenic determinants from amino acid sequences.

Thomas P. Hopp, Kenneth R. Woods · Proceedings of the National Academy of Sciences · 1981 · 3.7K citations · Full text

Immunology, Escherichia Coli, Antigen Processing +16

Rational Design of a Potent, Long-Lasting Form of Interferon:  A 40 kDa Branched Polyethylene Glycol-Conjugated Interferon α-2a for the Treatment of Hepatitis C

Pascal Bailon, Alicia V. Palleroni, Carol Ann Schaffer et al. · Bioconjugate Chemistry · 2001 · 609 citations

Interferon Alpha-2a, Translational Medicine, Ethylene Glycol +15

Prediction of sequential antigenic regions in proteins

Gjalt W. Welling, Wicher J. Weijer, Ruurd van der Zee et al. · FEBS Letters · 1985 · 359 citations · Full text

Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

Nancy J. Ganson, Susan J. Kelly, Edna Scarlett et al. · Arthritis Research & Therapy · 2005 · 341 citations · Full text

Structural Basis for the Entrance into the Phenylpropanoid Metabolism Catalyzed by Phenylalanine Ammonia-Lyase

Holger Ritter, Georg E. Schulz · The Plant Cell · 2004 · 289 citations · Full text