Edna Scarlett

Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

Nancy J. Ganson, Susan J. Kelly, Edna Scarlett et al. · Arthritis Research & Therapy · 2005 · 343 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

Michael S. Hershfield, Nancy J. Ganson, Susan J. Kelly et al. · Arthritis Research & Therapy · 2014 · 267 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +16

Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout

John S. Sundy, Nancy J. Ganson, Susan J. Kelly et al. · Arthritis & Rheumatism · 2007 · 219 citations

Medicine, Clinical Pharmacokinetics, Pharmacology +16

Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo

Michael S. Hershfield, L. Jackson Roberts, Nancy J. Ganson et al. · Proceedings of the National Academy of Sciences · 2010 · 144 citations

Life Sciences, Biochemistry, Pharmacology +17