Michael S. Hershfield

Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

Qing Zhou, Dan Yang, Amanda K. Ombrello et al. · New England Journal of Medicine · 2014 · 893 citations · Full text

Life Sciences, Genetics, Neurology +14

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

Donald B. Kohn, Kenneth I. Weinberg, Jan A. Nolta et al. · Nature Medicine · 1995 · 611 citations · Full text

Pharmacy, Molecular Biology, Pediatrics +15

Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

Michael S. Hershfield, Rebecca H. Buckley, Michael Greenberg et al. · New England Journal of Medicine · 1987 · 447 citations

Life Sciences, Biochemistry, Pharmacology +16

Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

Nancy J. Ganson, Susan J. Kelly, Edna Scarlett et al. · Arthritis Research & Therapy · 2005 · 343 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.

C. Glenn Begley, PD Aplan, Michael P. Davey et al. · Proceedings of the National Academy of Sciences · 1989 · 285 citations · Full text

Life Sciences, Genetics, Molecular Biology +17