Concepedia

Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH

Naohito Shirai, Takahisa Furuta, Yasushi Moriyama, Hideaki Okochi, Kaoru Kobayashi, Miyuki Takashima, Kazuhiro Kosuge, Kazuko Nakagawa, Hiroyuki Hanai, Kazuhiro Chiba,

Alimentary Pharmacology & Therapeutics · 2001 · 219 citations · 25 references

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Abstract

The acid inhibitory effects of omeprazole and rabeprazole are significantly dependent on the CYP2C19 genotype status, as well as on their intrinsic pharmacokinetic and pharmacodynamic characteristics and dosing schemes.

References

25

Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota

G. Richard Locke, N. J. Talley, A. R. Zinsmeister et al. · Gastroenterology · 1997 · 2.1K citations · Full text

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Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

Sara Moráis, G. Wilkinson, Joyce Blaisdell et al. · Molecular Pharmacology · 1994 · 750 citations

Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase

E. Fellenius, T. Berglindh, George Sachs et al. · Nature · 1981 · 623 citations

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Long-Term Treatment with Omeprazole for Refractory Reflux Esophagitis: Efficacy and Safety

Elly C. Klinkenberg–Knol · Annals of Internal Medicine · 1994 · 430 citations

Genotyping of S-mephenytoin 4′-hydroxylation in an extended Japanese population*

Takahiro Kubota, Kan Chiba, Takashi Ishizaki · Clinical Pharmacology & Therapeutics · 1996 · 288 citations