Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

Richard Marais, Judy Wynne, Richard Treisman · Cell · 1993 · 1.3K citations

Transcriptional Regulation, Systems Biology, Developmental Biology +8

Expressed protein ligation: A general method for protein engineering

Tom W. Muir, Dolan Sondhi, Philip A. Cole · Proceedings of the National Academy of Sciences · 1998 · 1.2K citations · Full text

A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins

Christopher J. Noren, Spencer J. Anthony‐Cahill, Michael Griffith et al. · Science · 1989 · 1K citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

Peter Hof, Scott Pluskey, Sirano Dhe‐Paganon et al. · Cell · 1998 · 990 citations · Full text

Crystal Structure, Biochemistry, Protein X-ray Crystallography +3

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

Zhou Songyang, Steven E. Shoelson, Jane McGlade et al. · Molecular and Cellular Biology · 1994 · 878 citations · Full text

Structural Bioinformatics, Signal Recognition, Molecular Biology +22