Concepedia

Anti-Fibrotic Actions of Interleukin-10 against Hypertrophic Scarring by Activation of PI3K/AKT and STAT3 Signaling Pathways in Scar-Forming Fibroblasts

Jihong Shi, Jun Li, Hao Guan, Weixia Cai, Xiaozhi Bai, Xiaobing Fang, Xiaolong Hu, Yaojun Wang, Hongtao Wang, Zhao Zheng,

PLoS ONE · 2014 · 119 citations · 23 references

DOIFull text

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Abstract

IL-10 apparently inhibits fibrosis by activating AKT and STAT3 phosphorylation downstream of the IL-10 receptor, and by facilitating crosstalk between the PI3K/AKT and STAT3 signal transduction pathways.

References

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