Concepedia

siRNA Silencing of the Mutant Keratin 12 Allele in Corneal Limbal Epithelial Cells Grown From Patients With Meesmann's Epithelial Corneal Dystrophy

David Courtney, Sarah D. Atkinson, Edwin H. A. Allen, Jonathan E. Moore, Colum P. Walsh, Deena M. Leslie Pedrioli, C J MacEwen, Graziella Pellegrini, Eleonora Maurizi, Chiara Serafini,

Investigative Ophthalmology & Visual Science · 2014 · 36 citations · 32 references

DOIFull text

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Abstract

Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals.

References

32

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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Mark E. Davis, Jonathan E. Zuckerman, Chung Hang Jonathan Choi et al. · Nature · 2010 · 2.5K citations · Full text

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Kerato-epithelin mutations in four 5q31-linked corneal dystrophies

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John P. DeVincenzo, Rob Lambkin‐Williams, Tom Wilkinson et al. · Proceedings of the National Academy of Sciences · 2010 · 434 citations · Full text

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