Concepedia

Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90

Daniela Trisciuoglio, Chiara Gabellini, Marianna Desideri, Elio Ziparo, Gabriella Zupi, Donatella Del Bufalo

PLoS ONE · 2010 · 90 citations · 38 references

DOIFull text

Open access

Abstract

We identified the stabilization of HIF-1alpha protein as a mechanism through which bcl-2 induces the activation of HIF-1 in hypoxic tumour cells involving the beta isoform of molecular chaperone HSP90.

References

38

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

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NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Jordi Rius, Mónica Gumá, Christian Schachtrup et al. · Nature · 2008 · 1.5K citations · Full text

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1  in normoxia

Edurne Berra · The EMBO Journal · 2003 · 1.3K citations · Full text

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Bcl-2 family members: Dual regulators of apoptosis and autophagy

Beth Levine, Sangita C. Sinha, Guido Kroemer · Autophagy · 2008 · 803 citations · Full text

Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation

Joo-Won Jeong, Moon-Kyoung Bae, Mee-Young Ahn et al. · Cell · 2002 · 712 citations · Full text

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