Concepedia

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

Akiko Kumagai, William G. Dunphy

Molecular Cell · 2000 · 426 citations · 29 references

DOIFull text

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Concepts

References

29

Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

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Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Satomi Matsuoka · 1998 · 1.3K citations

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Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Yolanda Sánchez, Calvin Wong, Richard S. Thoma et al. · Science · 1997 · 1.3K citations

, , +17

<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

Eric J. Brown, David Baltimore · Genes & Development · 2000 · 944 citations · Full text

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Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Seong‐Tae Kim, Dae‐Sik Lim, Christine E. Canman et al. · Journal of Biological Chemistry · 1999 · 814 citations · Full text

, , +15