Concepedia

Replication Checkpoint Activation

Replication Checkpoint Activation is a regulatory mechanism in the cell cycle that functions as a surveillance system to halt DNA replication progression upon detection of replication stress or DNA damage, thereby ensuring genomic stability by preventing the initiation of mitosis before replication completion.

375

Publications

33.2K

Citations

1.6K

Authors

481

Institutions

Publications per year

2017–2026

43

Parents

Publications

375

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

José M. Sogo, Massimo Lopes, Marco Foiani · Science · 2002 · 821 citations

, , +17

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

Piers Nash, Xiaojing Tang, Stephen Orlicky et al. · Nature · 2001 · 759 citations

, , +13

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

Tony Byun, Marcin Pacek, Muh‐Ching Yee et al. · Genes & Development · 2005 · 757 citations · Full text

, , +17

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

Ralph Zellweger, Damian Dalcher, Karun Mutreja et al. · The Journal of Cell Biology · 2015 · 689 citations · Full text

, , +17

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

Corrado Santocanale, John F.X. Diffley · Nature · 1998 · 646 citations

, , +14

1–5 of 375

Authors

1.6K

  1. PR
    Paul Russell

    Scripps Research Institute, United States

    16 publications · 1.5K citations

    16

    h-index

  2. HM
    Hisao Masai

    Tokyo Metropolitan Institute of Medical Science, Japan

    10 publications · 464 citations

    10

    h-index

  3. JC
    Junjie Chen

    The University of Texas MD Anderson Cancer Center, United States

    7 publications · 760 citations

    7

    h-index

  4. ML
    Massimo Lopes

    University of Zurich, Switzerland

    7 publications · 2.1K citations

    7

    h-index

  5. JJ
    J. Julian Blow

    University of Dundee, United Kingdom

    6 publications · 1.2K citations

    6

    h-index

1–5 of 1.6K

Institutions

481

  1. Scripps Research Institute

    San Diego, United States

    20 h-index

    56 publications

    6.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    92 publications

    6.3K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    26 publications

    8K citations

  4. Harvard University

    Cambridge, United States

    12 h-index

    25 publications

    4K citations

  5. Cancer Research UK

    London, United Kingdom

    12 h-index

    28 publications

    4K citations

  6. University of Milan

    Milan, Italy

    11 h-index

    47 publications

    5.5K citations

  7. University of Dundee

    Dundee, United Kingdom

    11 h-index

    31 publications

    5.6K citations

  8. The Honourable Society of Lincoln's Inn

    London, United Kingdom

    10 h-index

    22 publications

    1.5K citations

1–8 of 481

Venues

  1. Journal of Biological Chemistry

    JBC · 49 publications · 3K citations

    35

    h-index

  2. Molecular and Cellular Biology

    MCB · 31 publications · 2.9K citations

    26

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 2.1K citations

    18

    h-index

  4. Nucleic Acids Research

    20 publications · 867 citations

    17

    h-index

  5. Genes & Development

    17 publications · 3.8K citations

    17

    h-index

1–5