Concepedia

Claspin Function

Claspin Function is a molecular adaptor mechanism that enables checkpoint kinase activation during DNA replication stress by facilitating Chk1 phosphorylation in response to replication fork stalling.

92

Publications

7K

Citations

448

Authors

159

Institutions

Publications per year

2017–2026

13

Parents

Publications

92

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

Akiko Kumagai, William G. Dunphy · Molecular Cell · 2000 · 426 citations · Full text

, , +15

SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

Angelo Peschiaroli, N. Valerio Dorrello, Daniele Guardavaccaro et al. · Molecular Cell · 2006 · 285 citations · Full text

, , +12

Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress

Niels Mailand, Simon Bekker‐Jensen, Jiří Bártek · Molecular Cell · 2006 · 253 citations

, , +15

Human Claspin Is Required for Replication Checkpoint Control

Claudia C.S. Chini, Junjie Chen · Journal of Biological Chemistry · 2003 · 237 citations · Full text

, , +17

Adaptation of a DNA Replication Checkpoint Response Depends upon Inactivation of Claspin by the Polo-like Kinase

Hae Yong Yoo, Akiko Kumagai, Anna Shevchenko et al. · Cell · 2004 · 221 citations · Full text

, , +15

1–5 of 92

Authors

448

  1. WG
    William G. Dunphy

    California Institute of Technology, United States

    10 publications · 1.5K citations

    10

    h-index

  2. AK
    Akiko Kumagai

    California Institute of Technology, United States

    6 publications · 1.2K citations

    6

    h-index

  3. HM
    Hisao Masai

    Tokyo Metropolitan Institute of Medical Science, Japan

    6 publications · 402 citations

    6

    h-index

  4. RF
    Raimundo Freire

    Hospital Universitario de Canarias, Spain

    5 publications · 490 citations

    5

    h-index

  5. JL
    Joon Lee

    California Institute of Technology, United States

    4 publications · 412 citations

    4

    h-index

1–5 of 448

Institutions

159

  1. California Institute of Technology

    Pasadena, United States

    10 h-index

    27 publications

    3.8K citations

  2. Harvard University

    Cambridge, United States

    9 h-index

    45 publications

    3.3K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    7 h-index

    34 publications

    2.3K citations

  4. Tokyo Metropolitan Institute of Medical Science

    Tokyo, Japan

    6 h-index

    29 publications

    1.8K citations

  5. Hospital Universitario de Canarias

    Tenerife, Spain

    6 h-index

    17 publications

    1.7K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    13 publications

    2.7K citations

  7. Massachusetts General Hospital

    Boston, United States

    5 h-index

    25 publications

    1.3K citations

  8. Mayo Clinic

    Rochester, United States

    4 h-index

    13 publications

    1.3K citations

1–8 of 159

Venues

  1. Journal of Biological Chemistry

    JBC · 11 publications · 1.1K citations

    11

    h-index

  2. Cell Cycle

    9 publications · 370 citations

    9

    h-index

  3. Molecular Cell

    6 publications · 1.3K citations

    6

    h-index

  4. Molecular Biology of the Cell

    MBC · 5 publications · 362 citations

    5

    h-index

  5. Nucleic Acids Research

    5 publications · 263 citations

    5

    h-index

1–5