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Efficacy of Glucarpidase (Carboxypeptidase <scp>G</scp> 2) in Patients with Acute Kidney Injury After High‐Dose Methotrexate Therapy

Brigitte C. Widemann, Stefan Schwartz, Nalini Jayaprakash, Robbin Christensen, Ching‐Hon Pui, Nikhil Chauhan, Claire Daugherty, Thomas King, Janet E. Rush, Scott C. Howard

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · 2013 · 87 citations · 23 references

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Abstract

Glucarpidase caused a clinically important 99% or greater sustained reduction of serum methotrexate levels and provided noninvasive rescue from methotrexate toxicity in renally impaired patients.

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