High dose methotrexate with leucovorin rescue

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

Sidney Farber, Louis K. Diamond, Robert D. Mercer et al. · New England Journal of Medicine · 1948 · 1.8K citations

Hematological Malignancy, Temporary Remissions, Antibiotics +14

Methotrexate: Distribution in Cerebrospinal Fluid after Intravenous, Ventricular and Lumbar Injections

William R. Shapiro, Dean F. Young, Bipin M. Mehta · New England Journal of Medicine · 1975 · 679 citations

Plasma Creatinine Determination A New and Specific Jaffe Reaction Method

C. Slot · Scandinavian Journal of Clinical and Laboratory Investigation · 1965 · 566 citations

Renal Function, Biochemistry, Scandinavian Journal +10

Use of Plasma Pharmacokinetics to Predict and Prevent Methotrexate Toxicity

Ronald G. Stoller, Kenneth R. Hande, Samuel A. Jacobs et al. · New England Journal of Medicine · 1977 · 395 citations

Drug Safety, Standard Deviations, Pharmacokinetic Modeling +12

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

I. David Goldman, New Lichtenstein, Vincent T. Oliverio · Journal of Biological Chemistry · 1968 · 376 citations · Full text

Mixed-phenotype Acute Leukemia, Folic Acid Analogue, Cellular Physiology +19