Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · PubMed · 1997 · 979 citations

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Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

Frank J. Gonzalez, Radek C. Skodat, Shioko Kimura et al. · Nature · 1988 · 718 citations

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Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

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Medicine, Genetics, Molecular Genetics +16

The hypoalgesic effect of tramadol in relation to CYP2D6*

Lars K. Poulsen, Lars Arendt‐Nielsen, Kim Brøsen et al. · Clinical Pharmacology & Therapeutics · 1996 · 387 citations

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Impact of CYP2D6 genotype on postoperative tramadol analgesia

Ulrike M. Stamer, Katja Lehnen, Fabienne Höthker et al. · Pain · 2003 · 333 citations

Medicine, Pharmacokinetics, Pharmacology +17