Concepedia

Inhibition of thiopurine S -methyltransferase activity by impurities in commercially available substrates: a factor for differing results of TPMT measurements

T. Kröplin, Christine Fischer, H. Iven

European Journal of Clinical Pharmacology · 1999 · 26 citations · 17 references

DOI

Concepts

References

17

The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

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Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Richard M. Weinshilboum, S. L. Sladek · PubMed · 1980 · 1.2K citations

A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors (Short Communication)

Athel Cornish‐Bowden · Biochemical Journal · 1974 · 932 citations · Full text

Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism

Lynne Lennard, Jon A. Van Loon, Richard M. Weinshilboum · Clinical Pharmacology & Therapeutics · 1989 · 598 citations

Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties

Richard M. Weinshilboum, F.A. Raymond, P.A. Pazmiño · Clinica Chimica Acta · 1978 · 346 citations

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