American Journal of Hematology · 2002 · 40 citations · 6 references
MedicineHematologyPharmacologyHematology PhysiologyHematopathologyPediatric HematologyAnemiaHemoglobin PhysiologyProtein SynthesisRed Blood Cell DisordersRed Blood Cell PhysiologySickle Cell DiseaseErk SignalingHemoglobin Synthesis DefectsKinase InhibitorsMitogen-activated Protein Kinase KinaseProtein Kinase G SignalingProtein Kinase InhibitorsSickle Cell AnemiaWestern Blot Analysis
Valproate has been found to stimulate fetal hemoglobin (HbF) synthesis in patients with sickle cell disease. In accordance with these clinical observations, we found a moderate induction of HbF synthesis in K562 erythroid cells in vitro. Investigation of the role of the mitogen-activated protein kinase (MAPK) pathways by Western blot analysis and use of specific kinase inhibitors suggests that inhibition of ERK pathway and activation of the p38 pathway may contribute to the HbF-inducing activity of valproate.
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Stimulation of fetal hemoglobin production by short chain fatty acids
Effie Liakopoulou, CA Blau, Q Li et al. · Blood · 1995 · 75 citations · Full text