Valproic Acid and Augmentation of Fetal Hemoglobin in Individuals With and Without Sickle Cell Disease

Abstract

To the Editor: Increased synthesis of fetal hemoglobin may ameliorate the clinical severity of sickle cell disease1; both chemotherapeutic and nonchemotherapeutic agents have been shown to augment fetal hemoglobin synthesis in selected populations of affected patients.[2][1] ,[3][2] Some studies