Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.

O Platt, Stuart H. Orkin, G Dover, +3

Journal of Clinical Investigation

Dna BasesLaboratory HematologyHeme HomeostasisPhysiologyHematology +8

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

Samuel Charache, G Dover, Kerry Smith, +3

Proceedings of the National Academy of Sciences

AnemiaImmunohematologyLaboratory HematologyGeneticsHematology +12

Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both.

Stylianos E. Antonarakis, C D Boehm, G. R. Serjeant, +3

Proceedings of the National Academy of Sciences

Recurrent MutationGeneticsHuman PolymorphismMolecular GeneticsMolecular Ecology +14

A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy

KR Bridges, GD Barabino, Carlo Brugnara, +8

Blood

Impact of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia.

Steven D. Gore, Li Weng, S. Zhai, +11

PubMed

Hematological MalignancyNeuro-oncologyOncologyMixed-phenotype Acute LeukemiaAcute Myeloid Leukemia +10

5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin.

R. Keith Humphries, G Dover, NS Young, +4

Journal of Clinical Investigation

ImmunologyBlood CellSevere ThalassemiaEmbryologyOxidative Stress +14

Stimulation of fetal hemoglobin production by short chain fatty acids

Effie Liakopoulou, CA Blau, Q Li, +7

Blood

Butyrate derivatives. New agents for stimulating fetal globin production in the beta-globin disorders.

Susan P. Perrine, N F Olivieri, D V Faller, +3

PubMed

Administration of erythropoietin to patients with beta-thalassemia intermedia: a preliminary trial [letter]

EA Rachmilewitz, Ada Goldfarb, G Dover

Blood

Laboratory HematologyTransfusion MedicineHematologyBeta-thalassemia IntermediaMedicine +1

Alpha thalassemia changes erythrocyte heterogeneity in sickle cell disease.

Constance Tom Noguchi, G Dover, Griffin P. Rodgers, +6

Journal of Clinical Investigation

AnemiaImmunohematologyLaboratory HematologyMedicinePhysiology +9