Concepedia

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

Jessica L. Yecies, Huihui Zhang, Suchithra Menon, Sihao Liu, Derek Yecies, Alex Lipovsky, Cem Z. Görgün, David J. Kwiatkowski, Gökhan S. Hotamışlıgil, Chih‐Hao Lee,

Cell Metabolism · 2011 · 634 citations · 43 references

DOIFull text

Open access

Concepts

References

43

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature · 1995 · 5.2K citations

, , +12

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Jay D. Horton, Joseph L. Goldstein, Michael S. Brown · Journal of Clinical Investigation · 2002 · 4K citations · Full text

, , +17

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Düvel, Jessica L. Yecies, Suchithra Menon et al. · Molecular Cell · 2010 · 2K citations · Full text

, , +13

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Han Cho, James Mu, Jason K. Kim et al. · Science · 2001 · 1.8K citations

, , +17

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Li Yu, Shanqin Xu, Maria M. Mihaylova et al. · Cell Metabolism · 2011 · 1.7K citations · Full text

, , +17