Concepedia

Publication | Open Access

The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells

DOIFull Paper Access

58

Citations

35

References

2015

Year

Fangyong Dong, Michael Eibach, Jörg W. Bartsch, Amalia M. Dolga, Uwe Schlomann, Catharina Conrad, Susanne Schieber, Oliver Schilling, Martin L. Biniossek, Carsten Culmsee,
Neuro-Oncology

Abstract

ADAM8 causes TMZ resistance in GBM cells by enhancing pAkt/PI3K, pERK1/2, and cleavage of CD44 and HGF R/c-met. Specific ADAM8 inhibition can optimize TMZ chemotherapy of GBM in order to prevent formation of recurrent GBM in patients.

References

YearCitations

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