GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.3K citations · Full text

Genome Instability, Novel Gene, Genetic Disorder +10

Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer · Cell · 2008 · 6.9K citations · Full text

Cell Autophagy, Mitophagy, Autoimmune Disease +10

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Heather P. Harding, Isabel Novoa, Yuhong Zhang et al. · Molecular Cell · 2000 · 3.2K citations · Full text

Transcriptional Regulation, Developmental Biology, Cell Regulation +7

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3K citations

Signal Transduction, Signaling Pathway, Cell Regulation +5

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

Nutrient-sensitive Complex, Cell Growth Machinery, Signal Transduction +12