The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.7K citations

Life Sciences, Biochemistry, Biomolecular Modeling +16

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

En Li, Timothy H. Bestor, Rudolf Jaenisch · Cell · 1992 · 4K citations

Life Sciences, Genetics, Molecular Biology +14

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

Axel T. Brünger · Nature · 1992 · 3.9K citations

Natural Sciences, Chemistry, Physics +16

Accurate bond and angle parameters for X-ray protein structure refinement

Richard A. Engh, Robert Huber · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 2.5K citations

Natural Sciences, Biophysics, Crystal Structure +16

Role for DNA methylation in genomic imprinting

Rudolf Jaenisch · Nature · 1993 · 2K citations

Life Sciences, Genetics, Molecular Genetics +14