Concepedia

TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation

Renfang Mao, Yihui Fan, Yonggao Mou, Hong Zhang, Songbin Fu, Jianhua Yang

Cellular Signalling · 2010 · 74 citations · 14 references

DOI

Concepts

References

14

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Chen Wang, Li Deng, Mei Hong et al. · Nature · 2001 · 2.1K citations

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Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

Kyoko Shirakabe, Hiroshi Shibuyà, Kenji Irie et al. · Science · 1995 · 1.3K citations

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Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

Mireille Delhase, Makio Hayakawa, Yi Chen et al. · Science · 1999 · 869 citations

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Jae‐Hyuck Shim, Changchun Xiao, Amber Paschal et al. · Genes & Development · 2005 · 729 citations · Full text

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TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway

Giichi Takaesu, Satoshi Kishida, Atsushi Hiyama et al. · Molecular Cell · 2000 · 608 citations · Full text

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