ChemBioChem · 2007 · 52 citations · 16 references
Life SciencesBiochemistryCancer BiologyDrug DiscoveryEnzymologyMetabolic EngineeringGlycan BiosynthesisMetabolic Pathway EngineeringAnticancer ActivityAntiproliferative Drug ActionGlycosyltransferase FunctionGlycosyltransferase PathwaysHeterologous Expression SystemsHeterologous Gene Expression
Add sugar…︁ Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase, AraGT, which accepts different nucleotide-activated sugars (D-amicetose, L-rhodinose, L-rhamnose and L-axenose) The newly generated aranciamycin derivatives displayed antiproliferative activity against MaTu and MCF7 cells; this shows that the deoxysugar is important for anticancer activity.
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