Organic Letters · 2005 · 79 citations · 30 references
Natural SciencesChemical EngineeringChemistryBiocatalysisCatalysisOrganic ChemistryCatalyst PreparationCatalytic MechanismsEnzymatic CatalysisAsymmetric CatalysisCatalytic Reaction MechanismsChiral Catalyst DesignEnantioselective CatalysisEnantioselective SynthesisHydrogenation CatalysisHydrogenation ReactionsOrganic Substrates
[reaction: see text] Monodentate phosphoramidites, in particular PipPhos and its octahydro analogue, are excellent ligands for the rhodium-catalyzed asymmetric hydrogenation of aromatic enol acetates, enol carbamates, and 2-dienol carbamates up to 98% ee. These latter substrates were hydrogenated selectively to the carbamates of the allyl alcohol.
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