Concepedia

A statistical analysis of in vitro human microsomal metabolic stability of small phenyl group substituents, leading to improved design sets for parallel SAR exploration of a chemical series

Alexander G. Dossetter

Bioorganic & Medicinal Chemistry · 2010 · 50 citations · 39 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryMetabolic StabilityMetabolismChemical Space AnalysisMetabolic Stability EnhancementMetabolic Stability OptimizationMicrosomal StabilityStructure-metabolism RelationshipsChemical Series AnalysisChemical Series OptimizationHigh-throughput Microsomal Stability ScreeningMetabolic Stability ModelingMetabolic Stability ScreeningMetabolic Stability TestingStructure - Metabolism Relationship AnalysisStructure-based Metabolic Optimization

References

39

A Multiple Comparison Procedure for Comparing Several Treatments with a Control

Charles W. Dunnett · Journal of the American Statistical Association · 1955 · 5.9K citations

Public Health, Biostatistics, Experimental Design +6

The Many Roles for Fluorine in Medicinal Chemistry

William K. Hagmann · Journal of Medicinal Chemistry · 2008 · 3.6K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +5

Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications

Clyde Young Kramer · Biometrics · 1956 · 3.1K citations

Public Health, Biostatistics, Experimental Design +9

Neighborhood Behavior: A Useful Concept for Validation of “Molecular Diversity” Descriptors

David E. Patterson, Richard D. Cramer, Allan M. Ferguson et al. · Journal of Medicinal Chemistry · 1996 · 514 citations

Pharmacy, Medicinal Chemistry, Drug Design +16

Utilization of operational schemes for analog synthesis in drug design

John G. Topliss · Journal of Medicinal Chemistry · 1972 · 459 citations

Pharmacy, Medicinal Chemistry, Pharmacology +5