Concepedia

Metabolic Stability Testing

Metabolic Stability Testing is a systematic experimental method used in drug discovery to assess the susceptibility of a compound to enzymatic degradation, particularly in hepatic tissues, thereby determining its likelihood of undergoing extensive first-pass metabolism.

197

Publications

9.1K

Citations

1.6K

Authors

364

Institutions

Publications per year

2017–2026

59

Parents

Publications

197

Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate.

B Lloyd, J. M. Burrin, P. Smythe et al. · Clinical Chemistry · 1978 · 584 citations

, , +14

(R)-Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability

Vasiliki Abadji, Sonyuan Lin, Gihan Taha et al. · Journal of Medicinal Chemistry · 1994 · 349 citations · Full text

, , +6

Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development.

Paweł Baranczewski, Andrzej Stańczak, Kathrin Sundberg et al. · PubMed · 2007 · 290 citations

, , +17

Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals

H. James Harwood, Stephen F. Petras, Lorraine D. Shelly et al. · Journal of Biological Chemistry · 2003 · 243 citations · Full text

, , +17

Metabolism and Anticancer Activity of the Curcumin Analogue, Dimethoxycurcumin

Constantin Tamvakopoulos, Konstantinos Dimas, Zacharias D. Sofianos et al. · Clinical Cancer Research · 2007 · 185 citations · Full text

, , +13

1–5 of 197

Authors

1.6K

  1. MW
    Mohamed W. Attwa

    King Saud University, Saudi Arabia

    11 publications · 289 citations

    11

    h-index

  2. AA
    Adnan A. Kadi

    King Saud University, Saudi Arabia

    10 publications · 264 citations

    10

    h-index

  3. HA
    Haitham AlRabiah

    King Saud University, Saudi Arabia

    6 publications · 156 citations

    6

    h-index

  4. AS
    Ali S. Abdelhameed

    King Saud University, Saudi Arabia

    4 publications · 135 citations

    4

    h-index

  5. HW
    Hany W. Darwish

    King Saud University, Saudi Arabia

    4 publications · 103 citations

    4

    h-index

1–5 of 1.6K

Institutions

364

  1. King Saud University

    Riyadh, Saudi Arabia

    12 h-index

    50 publications

    1.3K citations

  2. Pfizer (United States)

    New York, United States

    8 h-index

    113 publications

    8.8K citations

  3. Mansoura University Hospital

    Al Mansurah, Egypt

    8 h-index

    8 publications

    186 citations

  4. Bristol-Myers Squibb (Germany)

    Munich, Germany

    5 h-index

    12 publications

    718 citations

  5. Helmholtz Institute for Pharmaceutical Research Saarland

    Saarbrücken, Germany

    5 h-index

    11 publications

    238 citations

  6. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    5 h-index

    10 publications

    274 citations

  7. Saarland University

    Saarbrücken, Germany

    5 h-index

    22 publications

    446 citations

  8. Cairo University

    Giza, Egypt

    4 h-index

    7 publications

    203 citations

1–8 of 364

Venues

  1. Journal of Medicinal Chemistry

    36 publications · 2.1K citations

    24

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    8 publications · 215 citations

    8

    h-index

  3. Journal of Chromatography B

    7 publications · 171 citations

    7

    h-index

  4. Bioorganic & Medicinal Chemistry

    6 publications · 202 citations

    6

    h-index

  5. Journal of Pharmaceutical Sciences

    5 publications · 92 citations

    5

    h-index

1–5