Concepedia

Structure-based Metabolic Optimization

Structure-Based Metabolic Optimization is a computational framework that leverages molecular structure information to predict and refine metabolic transformations, distinguishing itself by integrating structural descriptors with metabolic feasibility constraints to guide the optimization of biochemical pathways.

9

Publications

837

Citations

75

Authors

22

Institutions

Publications per year

2017–2026

2

Parents

Publications

9

Atoms to Phenotypes: Molecular Design Principles of Cellular Energy Metabolism

Abhishek Singharoy, Christopher Maffeo, Karelia H. Delgado‐Magnero et al. · Cell · 2019 · 190 citations · Full text

, , +14

Optimization of molecular design in the evolution of metabolism: the glycogen molecule

Enrique Meléndez‐Hevia, Thomas K. Waddell, E D Shelton · Biochemical Journal · 1993 · 183 citations · Full text

, , +16

Discovery of new enzymes and metabolic pathways by using structure and genome context

Suwen Zhao, Ritesh Kumar, A. Sakai et al. · Nature · 2013 · 141 citations · Full text

, , +16

Prediction of binding modes for ligands in the cytochromes P450 and other heme‐containing proteins

Stewart B. Kirton, Christopher W. Murray, Marcel L. Verdonk et al. · Proteins Structure Function and Bioinformatics · 2005 · 101 citations

, , +17

Structure-Based Optimization of Arylamides as Inhibitors of Soluble Epoxide Hydrolase

Anne B. Eldrup, Fariba Soleymanzadeh, Steven J. Taylor et al. · Journal of Medicinal Chemistry · 2009 · 71 citations · Full text

, , +17

1–5 of 9

Authors

75

  1. RT
    Ryuichi Takase

    Kyoto University, Japan

    1 publications · 51 citations

    1

    h-index

  2. FS
    Fariba Soleymanzadeh

    Boehringer Ingelheim (United States), United States

    1 publications · 71 citations

    1

    h-index

  3. BH
    B. Hillerich

    Albert Einstein College of Medicine, United States

    1 publications · 141 citations

    1

    h-index

  4. RD
    Richard D. Taylor

    UCB Pharma (United Kingdom), United Kingdom

    1 publications · 101 citations

    1

    h-index

  5. SB
    Stewart B. Kirton

    University of Hertfordshire, United Kingdom

    1 publications · 101 citations

    1

    h-index

1–5 of 75

Institutions

22

  1. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    19 publications

    3.3K citations

  2. Universidad de La Laguna

    San Cristóbal de La Laguna, Spain

    1 h-index

    1 publications

    183 citations

  3. Kyoto University

    Kyoto, Japan

    1 h-index

    1 publications

    51 citations

  4. National Center for Supercomputing Applications

    Urbana, United States

    1 h-index

    1 publications

    190 citations

  5. University of Tennessee at Chattanooga

    Chattanooga, United States

    1 h-index

    2 publications

    366 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    1 publications

    190 citations

  7. Fudan University

    Shanghai, China

    1 h-index

    7 publications

    231 citations

  8. Constructor University

    Bremen, Germany

    1 h-index

    2 publications

    380 citations

1–8 of 22

Venues

  1. Journal of Biological Chemistry

    JBC · 1 publications · 51 citations

    1

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    1 publications · 17 citations

    1

    h-index

  3. European Journal of Medicinal Chemistry

    1 publications · 33 citations

    1

    h-index

  4. Biochemical Journal

    BJ · 1 publications · 183 citations

    1

    h-index

  5. Journal of Medicinal Chemistry

    1 publications · 71 citations

    1

    h-index

1–5