Role of p70S6K1-mediated Phosphorylation of eIF4B and PDCD4 Proteins in the Regulation of Protein Synthesis

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Estela Jacinto, Robbie Loewith, Anja Schmidt et al. · Nature Cell Biology · 2004 · 2.1K citations

Signal Transduction, Natural Sciences, Cell Interaction +10

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen, Seong A. Kang, Jae Won Chang et al. · Journal of Biological Chemistry · 2009 · 1.8K citations · Full text

A unifying model for mTORC1-mediated regulation of mRNA translation

Carson C. Thoreen, Lynne Chantranupong, Heather R. Keys et al. · Nature · 2012 · 1.5K citations · Full text

Systems Biology, Signal Transduction, Molecular Regulation +5

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

Arnim Pause, Graham J. Belsham, Anne‐Claude Gingras et al. · Nature · 1994 · 1.2K citations

Insulin Signaling, Signal Transduction, Biochemistry +10

mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

Marina K. Holz, Bryan A. Ballif, Steven P. Gygi et al. · Cell · 2005 · 1.2K citations · Full text

Signal Transduction, Dynamic Protein Interchange, Natural Sciences +9