Concepedia

Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases

Eun Jung Choi, Bong Jun Cho, David Lee, Yeo Hyeon Hwang, Sun Ha Chun, Hans H. Kim, In Ah Kim

BMC Cancer · 2014 · 115 citations · 33 references

DOIFull text

Open access

Abstract

Our results suggest possible strategies for counteracting the pro-survival signaling from EGFR to improve the therapeutic outcome of combined radiotherapy and TMZ for high-grade gliomas.

References

33

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Roger Stupp, Monika E. Hegi, Warren Mason et al. · The Lancet Oncology · 2009 · 7.7K citations

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Nature · 2008 · 7.6K citations · Full text

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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Roel G.W. Verhaak, Katherine A. Hoadley, Elizabeth Purdom et al. · Cancer Cell · 2010 · 7.5K citations · Full text

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<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma

Monika E. Hegi, Annie‐Claire Diserens, Thierry Gorlia et al. · New England Journal of Medicine · 2005 · 7.1K citations · Full text

The transcriptional network for mesenchymal transformation of brain tumours

Maria Stella Carro, Wei Keat Lim, Mariano J. Alvarez et al. · Nature · 2009 · 1.3K citations · Full text

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