Concepedia

Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Igor Klyubin, Dominic M. Walsh, Cynthia A. Lemere, William K. Cullen, Ganesh M. Shankar, Vicki Betts, E. T. C. Spooner, Liying Jiang, Roger Anwyl, Dennis J. Selkoe,

Nature Medicine · 2005 · 488 citations · 22 references

DOI

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References

22

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.3K citations

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Dale Schenk, Robin Barbour, Whitney Dunn et al. · Nature · 1999 · 3.2K citations

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Frédérique Bard, Catherine Cannon, Robin Barbour et al. · Nature Medicine · 2000 · 2K citations

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Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

Catriona McLean, Robert A. Cherny, Fiona Fraser et al. · Annals of Neurology · 1999 · 1.8K citations

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Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

Lih‐Fen Lue, Yu‐Min Kuo, Alex E. Roher et al. · American Journal Of Pathology · 1999 · 1.5K citations · Full text

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