Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva, +5

Nature

Synaptic PlasticityAlzheimer's DiseaseMolecular NeuroscienceAmyloid β ProteinMedicine +5

Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty

Shaomin Li, William K. Cullen, Roger Anwyl, +1

Nature Neuroscience

Synaptic PlasticityCognitive ScienceHippocampal Ca1Dopamine-dependent FacilitationNeurodynamics +9

Behavioural stress facilitates the induction of long-term depression in the hippocampus

Lin Xu, Roger Anwyl, Michael J. Rowan

Nature

Behavioural StressStress HormonePsychiatryBehavioral NeuroscienceMedicine +12

Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Igor Klyubin, Dominic M. Walsh, Cynthia A. Lemere, +8

Nature Medicine

Synaptic PlasticityNeurodegenerative DiseasesAlzheimer's DiseaseSynaptic NeuroscienceSynaptic Transmission +9

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

Jan Bieschke, Martin Herbst, Thomas Wiglenda, +17

Nature Chemical Biology

Protein NanoparticlesBiochemistryNatural SciencesProtein MisfoldingSmall Molecules +2

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

Qinwen Wang, Dominic M. Walsh, Michael J. Rowan, +2

Journal of Neuroscience

Synaptic TransmissionNeurotransmitterSynaptic SignalingSocial SciencesCell-derived Abeta +17

Stimulation on the Positive Phase of Hippocampal Theta Rhythm Induces Long-Term Potentiation That Can Be Depotentiated by Stimulation on the Negative Phase in Area CA1<i>In Vivo</i>

Christian Hölscher, Roger Anwyl, Michael J. Rowan

Journal of Neuroscience

Synaptic TransmissionHippocampal Theta RhythmNeurotransmissionSynaptic SignalingSocial Sciences +19

Amyloid β Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

Igor Klyubin, Vicki Betts, Alfred T. Welzel, +10

Journal of Neuroscience

Synaptic TransmissionImmunologySoluble Abeta OligomersNeurochemical BiomarkersSynaptic Signaling +16

Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus

Lin Xu, Roger Anwyl, Michael J. Rowan

Nature

Rat HippocampusCognitive ScienceNeuropsychologyNeurodynamicsBrain Mechanism +8

Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments

William K. Cullen, Yoo‐Hun Suh, Roger Anwyl, +1

Neuroreport