Concepedia

Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys

Timothy K. Hart, Richard M. Cook, Parnian Zia‐Amirhosseini, Elisabeth A. Minthorn, Teresa S. Sellers, Beverly E. Maleeff, Scot Eustis, Lester W. Schwartz, Ping Tsui, Edward R. Appelbaum,

Journal of Allergy and Clinical Immunology · 2001 · 241 citations · 40 references

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40

Immunol. Cell Biol.

Melinda Fitzgerald, Ian P. Hayward, Anita C. Thomas et al. · 1995 · 2.6K citations

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response

Margaret J Leckie, Anneke Ten Brinke, Jamey Khan et al. · The Lancet · 2000 · 1.8K citations

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Recombinant human interleukin 5 is a selective activator of human eosinophil function.

Angel F. López, Colin J. Sanderson, Jennifer R. Gamble et al. · The Journal of Experimental Medicine · 1988 · 959 citations · Full text

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Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

David B. Corry, Hans G. Folkesson, Martha L. Warnock et al. · The Journal of Experimental Medicine · 1996 · 727 citations · Full text

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Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

EJ Clutterbuck, EM Hirst, CJ Sanderson · Blood · 1989 · 680 citations

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