Concepedia

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

Angel F. López, Colin J. Sanderson, Jennifer R. Gamble, HD Campbell, IG Young, M A Vadas

The Journal of Experimental Medicine · 1988 · 959 citations · 21 references

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Abstract

Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils. This molecule is thus a prime candidate for the selective eosinophilia and eosinophil activation seen in disease.

References

21

Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.

Angel F. López, Dominic J. Williamson, Jennifer R. Gamble et al. · Journal of Clinical Investigation · 1986 · 717 citations · Full text

, , +17

Biologic properties in vitro of a recombinant human granulocyte- macrophage colony-stimulating factor

D Metcalf, C. Glenn Begley, GR Johnson et al. · Blood · 1986 · 455 citations

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A New Method for the Purification of Human Eosinophils and Neutrophils, and a Comparison of the Ability of These Cells to Damage Schistosomula of <i>Schistosoma Mansoni</i>

Mathew A. Vadas, John R. David, A Butterworth et al. · The Journal of Immunology · 1979 · 358 citations · Full text

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Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).

Hugh D. Campbell, William Q. J. Tucker, Yvonne Hort et al. · Proceedings of the National Academy of Sciences · 1987 · 325 citations · Full text

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The kinetics of chemotactic peptide-induced change in F-actin content, F-actin distribution, and the shape of neutrophils.

Thomas H. Howard, Christian Oresajo · The Journal of Cell Biology · 1985 · 312 citations · Full text

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