Concepedia

Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors

Cunlong Zhang, Chunyan Tan, Xuyu Zu, Xin Zhai, Feng Liu, Bizhu Chu, Xiaohua Ma, Ping Gong, Yuyang Jiang

European Journal of Medicinal Chemistry · 2011 · 44 citations · 32 references

DOI

Concepts

References

32

<i>MET</i> Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

Jeffrey A. Engelman, Kreshnik Zejnullahu, Tetsuya Mitsudomi et al. · Science · 2007 · 4.5K citations · Full text

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Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

Bhushan Nagar, William G. Bornmann, Patricia Pellicena et al. · PubMed · 2002 · 941 citations

, , +13

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl–mediated drug resistance

Jennifer S. Carew, Steffan T. Nawrocki, Charissa N. Kahue et al. · Blood · 2007 · 484 citations · Full text

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Beth Apsel, Jimmy A. Blair, Beatriz González et al. · Nature Chemical Biology · 2008 · 439 citations · Full text

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Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

T Skórski, Palanisamy Kanakaraj, Margaret Nieborowska-Skorska et al. · Blood · 1995 · 410 citations

, , +13