Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

T Skórski, Palanisamy Kanakaraj, Margaret Nieborowska-Skorska, +5

Blood

Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis.

Malgorzata Nieborowska-Skorska, Grażyna Hoser, Andrea Morrione, +5

PubMed

Pi3k InhibitorsImmunologyPathologyActivated Tyrosine KinaseCancer Biology +16

De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells.

Manas Kumar Santra, T Skórski, Bruno Calabretta, +2

Proceedings of the National Academy of Sciences

PathologyCell ProliferationCell CycleDecorin Gene ExpressionCancer Biology +17

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

T Skórski, Margaret Nieborowska-Skorska, Nicholas C. Nicolaides, +5

Proceedings of the National Academy of Sciences

Hematological MalignancyMixed-phenotype Acute LeukemiaMalignant Blood DisorderAntisense OligodeoxynucleotidesImmunology +10

Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.

Margaret Nieborowska-Skorska, Linpei Xue, Qiongdan Zhang, +5

PubMed

ImmunologyActivated Tyrosine KinaseTranscription 5Cancer BiologyTumor Biology +15

Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth.

T Skórski, Palanisamy Kanakaraj, De-Hui Ku, +5

The Journal of Experimental Medicine

Tumor BiologyDevelopmental BiologySignal TransductionP21ras ExpressionCell Regulation +12

Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide.

T Skórski, Margaret Nieborowska-Skorska, C Barletta, +5

Journal of Clinical Investigation

Hematological MalignancyPhiladelphia Leukemic CellsMedicineMixed-phenotype Acute LeukemiaAntisense Oligodeoxynucleotides +12

Treatment of Philadelphia1 Leukemia in Severe Combined Immunodeficient Mice by Combination of Cyclophosphamide and bcr/abl Antisense Oligodeoxynucleotides

T Skórski, Malgorzata Nieborowska-Skorska, Danilo Perrotti, +6

JNCI Journal of the National Cancer Institute

Role of p53 in Hematopoietic Recovery After Cytotoxic Treatment

Mariusz A. Wasik, Mariusz Z. Ratajczak, Cinzia Sevignani, +5

Blood

Growth factor-dependent inhibition of normal hematopoiesis by N-ras antisense oligodeoxynucleotides.

T Skórski, Cezary Szczylik, Mariusz Z. Ratajczak, +3

The Journal of Experimental Medicine

ImmunologyBlood CellPathologyImmunologic MechanismImmunotherapy +15