Concepedia

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes

Norie Murayama, Naoko Imai, Takahisa Nakane, Makiko Shimizu, Hiroshi Yamazaki

Biochemical Pharmacology · 2007 · 135 citations · 15 references

Concepts

Antifungal AgentBiochemistryN-oxidized Metabolite FormationMedicineMedicinal FungiSecondary MetaboliteHuman Liver MicrosomesMicrobiologyNew Anti-fungal AgentPharmacologyRedox Biology

References

15

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Hepatology, Biochemistry, Carbon Monoxide-binding Pigment +9

Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone

Pamela A. Williams, José Cosme, Dijana Matak‐Vinković et al. · Science · 2004 · 804 citations

Drug Target, Aldo-keto Reductase, Molecular Biology +16

Identification of the Cytochrome P450 Enzymes Involved in the N-Oxidation of Voriconazole

Ruth Hyland, B. C. Jones, Dennis A. Smith · Drug Metabolism and Disposition · 2003 · 376 citations

THE DISPOSITION OF VORICONAZOLE IN MOUSE, RAT, RABBIT, GUINEA PIG, DOG, AND HUMAN

S. J. Roffey, Soren Cole, Pierre Comby et al. · Drug Metabolism and Disposition · 2003 · 316 citations

Drug metabolism by Escherichia coli expressing human cytochromes P450

Asit Parikh, Elizabeth M. J. Gillam, F. Peter Guengerich · Nature Biotechnology · 1997 · 287 citations

Pharmacology, Metabolic Model, Biochemistry +1