PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Tumor Biology, Medicine, Molecular Biology +9

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

Weibo Luo, Hongxia Hu, Ryan Chang et al. · Cell · 2011 · 1.4K citations · Full text

Pyruvate Kinase M2, Signal Transduction, Biochemistry +13

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang, Yan Xia, Haitao Ji et al. · Nature · 2011 · 1K citations · Full text

Nuclear Pkm2, Transcriptional Regulation, Signal Transduction +6

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Weiwei Yang, Yanhua Zheng, Yan Xia et al. · Nature Cell Biology · 2012 · 888 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +10

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Weiwei Yang, Yan Xia, David H. Hawke et al. · Cell · 2012 · 825 citations · Full text

Histone Modifications, Chromatin, Transcriptional Regulation +15