Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Andrew Plump, Jonathan D. Smith, Tony Hayek et al. · Cell · 1992 · 2.3K citations

Life Sciences, Genetics, Molecular Genetics +10

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Sunny H. Zhang, Robert L. Reddick, Jorge A. Piedrahita et al. · Science · 1992 · 2.2K citations

Life Sciences, Cardiology, Genetics +17

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Yutaka Nakashima, Andrew Plump, Elaine W. Raines et al. · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · 1994 · 1.7K citations

Veterinary Medicine, Cardiology, Pathobiology +17

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

Edward M. Rubin, Ronald M. Krauss, Elizabeth A. Spangler et al. · Nature · 1991 · 993 citations

Life Sciences, Biochemistry, Molecular Biology +15

Quantitative assessment of atherosclerotic lesions in mice

Beverly Paigen, A. W. Morrow, Patricia A. Holmes et al. · Atherosclerosis · 1987 · 960 citations

Medicine, Cardiology, Pathology +14