Cyclization in situ of enose-/ynose-nitrilimines: an expedient approach to the synthesis of chiral glycopyrazoles and pyrazolonucleosides

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters · 1975 · 5.1K citations

Natural Sciences, Chemistry, Catalysis +11

Pyrazole Ligands:  Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

Shaun R. Stauffer, Christopher J. Coletta, Rosanna Tedesco et al. · Journal of Medicinal Chemistry · 2000 · 760 citations

Medicine, Endocrinology, Pharmacology +17

Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant:  Lead Identification and SAR of 3- and 4-Substituted Derivatives

Michaël Génin, Carolyn Biles, Barb J. Keiser et al. · Journal of Medicinal Chemistry · 2000 · 378 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A Novel One-Pot Method for the Preparation of Pyrazoles by 1,3-Dipolar Cycloadditions of Diazo Compounds Generated in Situ

Varinder K. Aggarwal, Javier de Vicente, Roger V. Bonnert · The Journal of Organic Chemistry · 2003 · 278 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +8

Regioselective synthesis of 1,3,4,5-tetrasubstituted pyrazoles from Baylis–Hillman adducts

Ka Young Lee, Jeong Mi Kim · Tetrahedron Letters · 2003 · 212 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9