Concepedia
Nature · 1995 · 314 citations · 24 references
Life SciencesGeneticsMolecular BiologyApoptosisCell DifferentiationOncogenesOncogene ActivationOncogene MutationsProto-oncogene ActivationT Cell BiologyT Cell DifferentiationTranscription Factor OncogenesCellular OncogenesEts Family OncogenesProto-oncogene Mutation
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
En Li, Timothy H. Bestor, Rudolf Jaenisch · Cell · 1992 · 4K citations
Life Sciences, Genetics, Molecular Biology +14
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Yoichi Shinkai · Cell · 1992 · 2.6K citations
Life Sciences, Genetics, Immunology +14
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations
Life Sciences, Developmental Biology, Molecular Biology +12
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
L. D. Shultz, Peter A. Schweitzer, T. V. Rajan et al. · Cell · 1993 · 748 citations
Life Sciences, Genetics, Molecular Genetics +6
The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation
Bohdan Wasylyk, Christine Wasylyk, Pedro Flores et al. · Nature · 1990 · 507 citations
Medicine, Genetics, Molecular Biology +14