Effect of γ‐Oryzanol on Serum Lipid Peroxide Level and Clinical Symptoms of Patients with Climacteric Disturbances

Abstract

Abstract The effect of γ‐Oryzanol, ferulic acid esters obtained from rice oil, on climacteric disturbances was studied with special reference to lipid peroxide levels in the sera of patient. 300 mg of γ‐Oryzanol was administered daily to each patient for 4 to 8 weeks. In 85% of 40 cases the effect on the climacteric disturbance was judged by the Kupperman method to be significant. In patients with climacteric disturbances, serum lipid peroxide levels were high, but were reduced significantly after administration of γ‐Oryzanol. By its administration, total cholesterol, triglyceride and HDL‐cholesterol were improved in cases with hyperlipidemia (TC<220 mg/dl, TG<140 mg/dl, HDL‐chol.>;45 mg/dl). The atherogenic index was also considerably reduced. No side effects and no particular changes in functional tests were observed.