Hypoxia‐inducible factor‐1α is associated with angiogenesis, and expression of bFGF, PDGF‐BB, and EGFR in invasive breast cancer

Abstract

In invasive breast cancer, HIF-1alpha is associated with angiogenesis, and expression of growth factors bFGF and PDGF-BB, and the receptor EGFR. Thus, agents targeting HIF-1 may combine different pathways of inhibiting breast cancer growth, including angiogenesis and growth factors.