Concepedia

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Maniyan P. Padmanilayam, Bernard Scorneaux, Yuxiang Dong, Jacques Chollet, Hugues Matile, Susan A. Charman, Darren J. Creek, William N. Charman, Josefina Santo Tomas, Christian Scheurer,

Bioorganic & Medicinal Chemistry Letters · 2006 · 59 citations · 9 references

DOI

Concepts

References

9

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

, , +15

Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans

Katrin Palm, Patric Stenberg, Kristina Luthman et al. · Pharmaceutical Research · 1997 · 751 citations

, , +14

A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs

Mark C. Wenlock, Rupert P. Austin, Patrick Barton et al. · Journal of Medicinal Chemistry · 2003 · 537 citations

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Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides:  Charting a Workable Structure−Activity Relationship Using Simple Prototypes

Yuxiang Dong, Jacques Chollet, Hugues Matile et al. · Journal of Medicinal Chemistry · 2005 · 117 citations

, , +17