Synaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

Salvatore Oddo, Antonella Caccamo, Jason D. Shepherd et al. · Neuron · 2003 · 4.1K citations · Full text

Alzheimer's Disease, Dementia, Degenerative Disease +5

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Holly D. Oakley, Sarah L. Cole, Sreemathi Logan et al. · Journal of Neuroscience · 2006 · 3.4K citations · Full text

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

Melanie Meyer‐Luehmann, Tara L. Spires‐Jones, Claudia Prada et al. · Nature · 2008 · 986 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Amyloid-β Plaques +8

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

Sadim Jawhar, Anna Trawicka, Carolin Jenneckens et al. · Neurobiology of Aging · 2010 · 580 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Neurobiology Of Disease +10

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

Tracy O’Connor, Katherine R. Sadleir, Erika Maus et al. · Neuron · 2008 · 411 citations · Full text

Signal Transduction, Protein Expression, Natural Sciences +8