Telomere dysfunction is related to the intrinsic radio-resistance of human oral cancer cells

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Andrea Bodnár, Michel Ouellette, Maria Frolkis et al. · Science · 1998 · 4.9K citations

A DNA damage checkpoint response in telomere-initiated senescence

Fabrizio d’Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace et al. · Nature · 2003 · 2.7K citations

Chromatin, Genome Instability, Dna Damage +7

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jiřina Bártková, Zuzana Hořejšı́, Karen Koed et al. · Nature · 2005 · 2.7K citations

Chromatin, Tumor Biology, Genome Instability +11

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Sunil R. Hingorani, Lifu Wang, Asha S. Multani et al. · Cancer Cell · 2005 · 2.6K citations · Full text

Genome Instability, Pancreatic Cancer, Chromosomal Instability +7

Oxidative stress shortens telomeres

Thomas von Zglinicki · Trends in Biochemical Sciences · 2002 · 2.5K citations

Reactive Oxygen Specie, Medicine, Cell Biology +2